Functionalized Nanoparticles May Be A Useful Drug Carrier For Tumor Targeting

Functionalized nanoparticles (NP) may be a useful drug carrier for tumor targeting. According to recent research published in the journal Bioconjugate Chemistry, "In this study, selective cancer cell targeting of biodegradable poly(lactic acid) (PLA) NPs has been investigated in vitro. SKOV-3 (HER2 positive) ovarian cancer and Daudi (CD20 positive) lymphoma cell targeting was mediated by anti-HER2 (trastuzumab, Herceptin) and anti-CD20 (rituximab, Mabthera) monoclonal antibodies (mAbs), respectively." "The mAb against nonexpressed antigen serving on each cell as isotype matched irrelevant control. Two different targeting approaches have been studied, a direct method using antibody-labeled NPs (mAb-NPs) and a pretargeting method using...