Findings In Cancer Gene Therapy Provide New Insights

Reports from the United States and Germany highlight recent research on cancer gene therapy. Study 1: According to recent research from the United States, absent in melanoma 2 (AIM2) suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. "IFN-inducible proteins are known to mediate IFN-directed antitumor effects. The human IFN-inducible protein AIM2 gene encodes a 39-kDa protein, which contains a 200-amino-acid repeat as a signature of HIN-200 family (hematopoietic IFN-inducible nuclear proteins)," wrote I.F. Chen and colleagues, M.D. Anderson Cancer Center. "Although AIM2 is known to inhibit fibroblast cell growth in vitro, its antitumor activity has not been shown. Here, we showed th...