Other Cancer

Van Andel Research Institute (VARI) researchers have found a way to reverse resistance to sunitinib, a treatment that is currently the first line of defense against clear cell renal cell carcinoma (ccRCC), a deadly form of kidney cancer. Most patients who show a positive response to sunitinib develop a resistance to the drug after one year of treatment.

A new study, 'Combinatorial control of suicide gene expression by tissue-specific promoter and microRNA regulation for cancer therapy,' is now available. Transcriptional targeting using a tissue-specific cellular promoter is proving to be a powerful means for restricting transgene expression in targeted tissues.

Hallelujah, Kim Green remembers thinking. Her life was about to get easier. For close to a decade, she had been making regular trips to the hospital, spending full days hooked up to machines that delivered chemotherapy to fight her breast cancer.

A report, 'Virotherapy against malignant glioma stem cells,' is newly published data in Cancer Letters. Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo-and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success, researchers in the United States report.

Scientists discuss in 'Kaposi's sarcoma- associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3- specific' new findings in sarcoma. Sumoylation has emerged as a major post-translational modification of cellular proteins, affecting a variety of cellular processes.

Investigators publish new data in the report 'Multiple head and neck tumours and their genetic relationship.' Second primary tumours represent one of the major causes of failure in the treatment of head and neck cancer. Advances in early diagnosis and treatment have improved the patient's disease-specific survival, investigators in Italy report.

Researchers have demonstrated the safety of a potential vaccine against mesothelioma, a rare cancer associated primarily with asbestos exposure. The vaccine, which infuses uses a patient's own dendritic cells (DC) with antigen from the patient's tumor, was able to induce a T- cell response against mesothelioma tumors.

A combination of two targeted therapies already shown to be effective in breast cancer packs an effective one-two punch against a subset of gastric cancers that have a specific genetic mutation, a study at UCLA's Jonsson Comprehensive Cancer Center has found.

The rapidly growing field of nanotechnology and its future use in cosmetic products holds both enormous potential and potential concern for consumers. Currently, major cosmetic manufacturers have imposed a voluntary ban on the use of nanoparticles in products while they await a ruling from the Food and Drug Administration (FDA) regarding the safety of this technology.

US researchers have decoded the entire genome of patients to identify the root cause of their diseases paving the way towards individual genomic treatments, according to newly published studies.