Breast Cancer

A new way to deliver cancer-fighting drugs using tiny particles made from lipids and chemotherapy drugs may have the power to knock out malignancies with a one-two punch. The strategy holds promise for patients with many different kinds of cancers.

A new study, 'Vitamin D and calcium intakes and breast cancer risk in pre- and postmenopausal women,' is now available. Some evidence suggests that vitamin D may reduce breast cancer risk. Despite the biological interaction between vitamin D and calcium, few studies have evaluated their joint effects on breast cancer risk, scientists in Toronto, Canada report.

Researchers analyzing 2.5 million screening mammograms performed on nearly one million women found discrimination of cancerous from non- cancerous lesions improved over a nine-year period. Results of the study are published in the online edition of the journal Radiology.

A report, 'Breast cancers not detected at MRI: review of false-negative lesions,' is newly published data in Ajr American Journal of Roentgenology. The objective of our study was to determine the sensitivity of cancer detection at breast MRI using current imaging techniques and to evaluate the characteristics of lesions with false-negative examinations.

Shortening chemotherapy may not be a good course of treatment for some women with early-stage breast cancer, according to a study conducted by the National Surgical Adjuvant Breast and Bowel Project based at Allegheny General Hospital.

New research, 'Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation,' is the subject of a report. According to recent research from the United States, Mutations of the sequence-specific master regulator p53 that alter transactivation function from promoter response elements (RE) could result in changes in the strength of gene activation or spectra of genes regulated.

It has long been understood that one of the reasons most premenopausal women benefited from chemotherapy drugs after breast cancer surgery was because the drugs stop menstruation for a time, suppressing their ovaries and the estrogen they produce.

Investigators publish new data in the report 'Cyclophilin B as a co-regulator of prolactin-induced gene expression and function in breast cancer cells.' According to a study from the United States, The effects of prolactin (PRL) during the pathogenesis of breast cancer are mediated in part though Stat5 activity enhanced by its interaction with its transcriptional inducer, the prolyl isomerase cyclophilin B (CypB).

According to a study from the United States, The purpose of this study was to evaluate contrast- enhanced ultrasound and neural network data classification for determining the breast cancer response to bevacizumab therapy in a murine model. An ultrasound scanner operating in the harmonic mode was used to measure ultrasound contrast agent (UCA) time-intensity curves in vivo.

Exposure in the womb to chemicals like Bisphenol- A (BPA) and Diethylstilbestrol (DES) can increase an offspring's risk of breast cancer, researchers at Yale School of Medicine report in a study published in current issue of Hormones and Cancer, a journal of The Endocrine Society.