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A significant step forward has been taken in the understanding of how lupus works with the publication of four new studies identifying genes involved in this often debilitating chronic disease. Rheumatologist Mark K. Crow talks about the importance of the studies and the questions they leave unanswered, along with insights on next steps in lupus research.

Researchers have for the first time analyzed the antioxidant properties of olive oil, a product rich in polyphenols (natural antioxidants). They believe these antioxidants improve the lives of people suffering from oxidative stress, and are also highly beneficial for the prevention of cell aging and osteoporosis.

Scientists have identified multiple genes that are linked to systemic lupus erythematosus, a devastating autoimmune disease that affects between 1 million and 2 million Americans. The scientists also confirmed earlier findings linking lupus to several other genes -- highlighting the role that genetics plays in the disease.

Behavior therapy [exposure and response prevention (ERP)] and cognitive therapy (CT) have proven effective in the treatment of obsessive-compulsive disorder. Direct comparisons between these treatment modalities have exposed no differences in efficacy. However, very little research has been conducted into the differences between the change processes in ERP and CT. This investigation is a first attempt to study change by measuring scores on a weekly basis rather than at specific stages in the treatment and follow-up.

Drug treatment of neuroblastoma, a tumor of the nervous system in children, poses major problems. Scientists have been searching for substances that are suitable as a basis for developing better drugs. Now they have found a candidate: HC-toxin, which is isolated from a fungal plant pathogen. The substance from the maize pathogen reprograms neuroblastoma cells in such a way that they behave almost like healthy cells again.

The discovery that a molecule drives local tumor growth, as well as its ability to flourish and spread, opens a new window for understanding and treating cancer by taking aim at both cancer cells and their surrounding environment. Scientists found that a member of a common molecular family plays a role in the progress of a particularly resilient and aggressive pancreatic cancer, and that its influence is not restricted to that cancer.

Scientists have uncovered a specific genetic mutation that suppresses the development of systemic lupus, an incurable autoimmune disease that causes the body to attack itself. The research suggests potential targets for future drug development.

Researchers encourage men to weigh both the potential benefits and side effects of the drug finasteride before taking it to reduce prostate cancer risk. Analysis indicates that cost effectiveness and quality of life issues associated with taking the drug are not clear cut.

New research shows that by suppressing one of the genes that normally switches on in wound cells, wounds can heal faster and reduce scarring. This has major implications not just for wound victims but also for people who suffer organ tissue damage through illness or abdominal surgery.

Patients prone to heart disease may one day be told by physicians to avoid not only fatty foods and smoking but air pollution too. A new academic study has revealed that the smallest particles from vehicle emissions may be the most damaging components of air pollution in triggering plaque buildup in the arteries, which can lead to heart attack and stroke.