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Oregon Health & Science University Cancer Institute researchers have opened a new window into the roots of chronic myeloid leukemia (CML). "We are looking under the surface of CML to understand better where the cancer is coming from. We have discovered abnormal cells in the early stem cell population in some CML patients, which don't belong to the CML clone. These are abnormal cells that are not part of the CML clone," said Thomas Bumm, M.D., OHSU Cancer Institute member.

The sleep patterns of patients in the intensive care unit are so superficial that they barely spend any time in the restorative stages of sleep that aid in healing, UT Southwestern Medical Center physicians have found.

Psychiatrists remain divided as to how to define and classify the mood and anxiety disorders, the most common mental disorders. Authors of a new study explain that their findings support a proposed "fetal programming" model for depression and anxiety, which posits that prenatal stress may result in permanent maladaptive changes to the developing fetal brain.

Eating a Mediterranean diet and following national recommendations for physical activity are each associated with a reduced risk of death over a five-year period, according to two reports in the Dec. 10/24 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. Both studies use data from the National Institutes of Health-AARP Diet and Health Study, which began when questionnaires were returned from 566,407 AARP members age 50 to 71 in six states between 1995 and 1996.

Patients whose immune system responded to a peptide vaccine for leukemia enjoyed a median remission that was more than three times longer than nonresponders, according to researchers.

An Oregon Health & Science University Cancer Institute researcher has discovered that a particular hormone is responsible for driving a cancer enzyme to cause an often deadly red blood cell cancer. Researchers working with the cancer mutation in the JAK2 enzyme have found that the enzyme is dependent on the hormone TNF-alpha to grow and cause a red blood cell cancer called polycythemia vera, said principal investigator Thomas Bumm, M.D., Ph.D., OHSU Cancer Institute member.